ganized collagen fibrils; the intrinsic fluorescence of elastin can highlight the vulnerability of the lesion.
Multimodal label-free imaging offers a
way to monitor disease processes over
time with less physiological perturbation.
Now that there are turnkey multimodal
systems available, biomedical researchers
can combine these methodologies for a
more thorough understanding of disease
processes. Moreover, these microscopic
imaging techniques can pave the way for
developing specific molecular imaging
techniques that offer greater tissue depth
and even the potential for clinical utility.
Meet the authors
James Lopez is the confocal and multiphoton
sales application specialist at Olympus America
Inc. in Chicago; email: james.lopez@olympus.
com. Yiwei Jia is marketing manager of confocal laser scanning microscopes at Olympus
America Inc. in Center Valley, Pa.; email:
K.A. Kasischke et al (July 2, 2004). Neural ac-
tivity triggers neuronal oxidative metabolism
followed by astrocytic glycolysis. Science,
This article is the final installment in
a series. The first three articles in this
Adrian Pegoraro et al (October 2009).
CARS Microscopy Made Simple.
Angela Goodacre et al (October 2010).
Combining Second-Harmonic Generation
with Multiphoton Imaging. BioPhotonics.
Angela Goodacre and Dennis Donley
(September 2011). Intrinsic Fluorescence
Lights Up Cellular Components.
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